Characterization of the DNA gyrase from the thermoacidophilic archaeon Thermoplasma acidophilum.
نویسندگان
چکیده
Thermoplasma acidophilum is sensitive to the antibiotic drug novobiocin, which inhibits DNA gyrase. We characterized DNA gyrases from T. acidophilum strains in vitro. The DNA gyrase from a novobiocin-resistant strain and an engineered mutant were less sensitive to novobiocin. The novobiocin-resistant gyrase genes might serve as T. acidophilum genetic markers.
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عنوان ژورنال:
- Journal of bacteriology
دوره 187 24 شماره
صفحات -
تاریخ انتشار 2005